Chronic pain is a global health challenge, but conventional rodent models often fail to capture the complexity of human pain mechanisms. To address this gap, we’ve developed an advanced, human-relevant model using human induced pluripotent stem cells (hiPSCs) to produce dorsal horn neurons (DHNs) in just seven days—without the need for transcription factor overexpression. These neurons, confirmed by immunocytochemistry and RNA sequencing, exhibit a high degree of purity, with a balanced ratio of glutamatergic and GABAergic cells. They can form functional networks and, when co-cultured with hiPSC-derived nociceptors, generate activity patterns unique to the peripheral-central pain pathway. This scalable, syngeneic model provides an innovative platform for pain drug discovery, potentially enabling the development of more targeted and effective pain therapies.

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• 1M per vial CAT#5020M1-1M